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Just about any joint in the body can be affected by joint pain. However, quite often joint pain strikes in the fingers, knees, ankles, wrists, hips and shoulders. Knee pain is the most common form of joint pain.This is largely because we put a lot of strain on our knees when we put our full bodyweight on them as we move from place to place throughout the day, every day. Causes of joint pain Cardiac glycosides: Concomitant use of cardiac glycosides and NSAIDs in patients may exacerbate cardiac failure, reduce GFR and increase plasma glycoside levels.
Thrombocytopenia, leucopoenia, anaemia (including haemolytic and aplastic anaemia), agranulocytosis. Appropriate monitoring and advice are required for patients with a history of hypertension and congestive heart failure (NYHA-I) as fluid retention and oedema have been reported in association with NSAID therapy, including diclofenac. Bursitis is a condition that affects the small, synovial fluid-filled sacs – called bursae – that cushion the bones and tendons near your joints. Bursitis most often occurs in joints that are used in frequent, repetitive motions. The most common locations of burstitis are the shoulder, elbow, and hip. However, it can also occur in the knee, heel, or at the base of your big toe. Gout iv. reduce the incidence of angiographic cystoid macular oedema after cataract surgery but clinical significance remains to be established. Drugs known to cause hyperkalemia: Concomitant treatment with potassium-sparing diuretics, ciclosporin, tacrolimus or trimethoprim may be associated with increased serum potassium levels, which should therefore be monitored frequently (see section 4.4 Special warnings and precautions for use).The effective daily dose after ocular application of Voltarol Ophtha (approximately 0.25 - 0.5 mg diclofenac sodium) corresponds to less than 1% of the daily dose recommended for Voltarol in rheumatic indications.
Allergic conditions have been reported for ocular reactions such as conjunctival hyperaemia, allergic conjunctivitis, eyelid erythema, oedema, and pruritus, and systemic hypersensitivity reactions such as urticaria, rash, eczema, erythema, pruritus, cough and rhinitis. There are no data available on the use of topical formulations of diclofenac and its effects on fertility in humans. This medicine is available without prescription. However, you still need to use Voltarol carefully to get the best results from it. Note that this leaflet is revised on a regular basis with the latest information on your medicine. Please refer to the date at the end of the leaflet. As the cardiovascular risks of diclofenac may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically.Like all medicines, Diclofenac diethylammonium can cause side effects, although not everybody gets them. As with other nonsteroidal anti-inflammatory drugs including diclofenac, allergic reactions, including anaphylactic/anaphylactoid reactions, can also occur without earlier exposure to the drug (see section 4.8 Undesirable effects). Hypersensitivity reactions can also progress to Kounis syndrome, a serious allergic reaction that can result in myocardial infarction. Presenting symptoms of such reactions can include chest pain occurring in association with an allergic reaction to diclofenac. Although the pharmacokinetics of Voltarol are not impaired to any clinically relevant extent in elderly patients, nonsteroidal anti-inflammatory drugs should be used with particular caution in such patients who generally are more prone to adverse reactions. In particular it is recommended that the lowest effective dosage be used in frail elderly patients or those with a low body weight (see also Precautions) and the patient should be monitored for GI bleeding during NSAID therapy. The low systemic absorption of Voltarol Emulgel renders overdose very unlikely. However, undesirable effects, similar to those observed following an overdose of diclofenac tablets, can be expected if Voltarol Emulgel is inadvertently ingested (e.g. 1 tube of 100g contains the equivalent of 1000mg of diclofenac sodium). During the third trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the foetus to:
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